Compare Vacation Rentals & Airbnb in Santa Cruz

106 available vacation rental offers

7 nights
2
1
  • airbnb
  • booking
  • vrbo
  • expedia
  • priceline
  • tripadvisor
  • tripcom
  • sonder
  • homestay
  • hostelworld
  • hotelscom
  • agoda
Santa Cruz vacation rentals
Choose the perfect vacation accommodation
Price per night
Accommodation type
Rating

106 Rentals and Airbnb in Santa Cruz

Best family friendly Santa Cruz vacation rentals

Among the 106 accommodations in Santa Cruz, here are the 4 best family friendly rentals

Lodge La Puerta - Santa Cruz
10 20 reviews

Lodge La Puerta

apartment
This Colchagua Valley holiday home is located 4.4km from the centre of Santa Cruz, offering easy access to local restaurants.
The two-bedroom, two-bathroom property sleeps four, features a fully equipped kitchen, private garden with gas grill and fire pit, plus children's swings and a ping-pong table.
Maison à Santa Cruz, Région D'o'higgins, Chili - Santa Cruz
9.8 87 reviews

Maison à Santa Cruz, Région D'o'higgins, Chili

house
This two-bedroom house, perfect for four guests, is conveniently located in the Los Viñedos district of Santa Cruz, Colchagua, offering easy access to local amenities and schools.
The property features a kitchen with a fridge and freezer, air conditioning, parking, internet access, and a private patio; further details regarding proximity to Santa Cruz city centre would require additional information.
Casa Céntrica Santa Cruz Valle De Colchagua-ruta Del Vino Frente Al Casino Y A 500 Metros De La Plaza Ideal Para Teletrabajo Con Wifi Rápido - Santa Cruz
8.9 13 reviews

Casa Céntrica Santa Cruz Valle De Colchagua-ruta Del Vino Frente Al Casino Y A 500 Metros De La Plaza Ideal Para Teletrabajo Con Wifi Rápido

house, Santa Cruz
This three-bedroom house is situated in a peaceful neighbourhood just a short walk from the beach and a kilometre from Santa Cruz city centre.
The 150 square metre property offers a private terrace, a fully equipped kitchen, air conditioning, free Wi-Fi, and parking, perfect for families or groups of up to 11 guests.
Santa Cruz, Valle De Colchagua - Santa Cruz
9.9 17 reviews

Santa Cruz, Valle De Colchagua

apartment
This Santa Cruz house, steps from the Tinguiririca River and close to the Colchagua Casino and Museum, offers a central location convenient for exploring the town's attractions.
The three-bedroom, one-bathroom property sleeps four guests and includes a kitchen, parking, and internet access; nearby plazas provide family-friendly recreation.

Best Santa Cruz vacation rentals with parking

Acogedora Casa A Minutos Del Centro - Santa Cruz
9.9 18 reviews

Acogedora Casa A Minutos Del Centro

apartment
This two-bedroom flat in Santa Cruz is situated just minutes from the city centre, offering convenient access to local attractions and amenities.
This apartment for four guests includes air conditioning, private parking with an electric vehicle charging station (extra cost), and a master bedroom with an en-suite bathroom, making it suitable for both leisure and business stays.
Departamento Amoblado Full, Aire Ac - Santa Cruz
9.8 128 reviews

Departamento Amoblado Full, Aire Ac

apartment
This apartment is located in a peaceful residential area in Santa Cruz, just a short walk from the Casino Colchagua, the Enjoy Casino, the Museo Colchagua, and local restaurants. The apartment has received excellent user, location, and cleanliness ratings.
This comfortable flat is ideal for a family or group of friends, accommodating up to three guests. It features a well-equipped kitchen, free coffee and tea, cable TV, Wi-Fi, and parking.
Casa Mimbre Santa Cruz - Santa Cruz
10 3 reviews

Casa Mimbre Santa Cruz

house
This central Santa Cruz flat is located in the main district, a short walk from the Casino, the Plaza de Armas, and the Colchagua Museum.
This three-bedroom flat accommodates eight guests and features air conditioning, Wi-Fi, and a fully equipped kitchen, powered by photovoltaic panels for eco-friendly stays.
Casa De Luz, Full Equipada Con Estacionamiento. - Santa Cruz
10 228 reviews

Casa De Luz, Full Equipada Con Estacionamiento.

house
This two-bedroom apartment is located in a peaceful neighbourhood in Santa Cruz, just a 10-minute drive from the city centre. It has consistently received excellent ratings for its cleanliness, location, and overall guest experience.
The apartment comfortably accommodates up to four guests and includes a fully equipped kitchen with a gas stove, electric oven, and coffee maker. Guests can also enjoy the convenience of a washing machine, parking, and internet access.

Frequently Asked Questions about vacation rentals in Santa Cruz

  • What sports or outdoor activites can visitors enjoy in and around Santa Cruz?

    Santa Cruz is an adventure paradise! You can go trekking in the Andes, try fly fishing in the rivers, or go white-water rafting on the Baker River. There's also great kayaking and mountain biking in the area.
  • What are the best Airbnb and vacation rentals in Santa Cruz?

    Vibo Wine Lodge At Viu Manent, Como En Casa - - and Comfortable House With Swimmingpool are the most popular Airbnb and vacation rentals in Santa Cruz among travelers.

  • What amenities are commonly available in vacation rentals in Santa Cruz?

    Most vacation rentals in Santa Cruz offer basic amenities like Wi-Fi, a kitchen, and a bathroom. Some might have a fireplace, a patio, or even a hot tub. It's best to check the listing for specific amenities.
  • What are the most popular Airbnbs in Santa Cruz?

    Among the Airbnbs in Santa Cruz, Como En Casa - -, Comfortable House With Swimmingpool and Casa Madera - Diseño Y Tradición are the most popular ones.

  • What time of year is best to rent a vacation rental Santa Cruz?

    The best time to visit Santa Cruz depends on what you want to do. Summer (December to February) is the warmest and sunniest, perfect for outdoor activities. Winter (June to August) is snowy and ideal for skiing and snowboarding, though some attractions may be closed.
  • What are the best vacation rentals with a pool in Santa Cruz?

    Vibo Wine Lodge At Viu Manent, Comfortable House With Swimmingpool and El Refugio De Santa Cruz are the best vacation rentals with a pool in Santa Cruz.

  • What are the local dishes in Santa Cruz region?

    The local cuisine in Santa Cruz is hearty and influenced by the Patagonian landscape. Try the 'cordero al palo', a whole lamb roasted on a spit, or 'pastel de choclo', a savoury corn pie. You'll also find delicious seafood dishes, like 'centolla' (king crab) and 'merluza austral' (Patagonian hake).
  • What are the best rentals for families and kids in Santa Cruz?

  • What are the best rentals or Airbnbs with a jacuzzi in Santa Cruz?

    The best vacation rentals or Airbnb with a jacuzzi in Santa Cruz are Vibo Wine Lodge At Viu Manent, El Refugio De Santa Cruz and Nenquen Lodge.

Popular destinations

Best Santa Cruz vacation rentals with a balcony

Cómo En Casa Y Cerca Del Centro - Santa Cruz
No reviews

Cómo En Casa Y Cerca Del Centro

apartment, Santa Cruz
This Santa Cruz flat offers a convenient district location, providing straightforward access to the city centre and local attractions without being in the busiest areas.
This 80-square-metre flat accommodates up to nine guests, featuring one bedroom, two bathrooms, a fully equipped kitchen, a seating area with a fireplace, and a terrace, with complimentary private parking and free high-speed WiFi included.
Cabañas Refugio Nativo - Santa Cruz
9.2 98 reviews

Cabañas Refugio Nativo

chalet, Santa Cruz
Cabañas Refugio Nativo is located in Santa Cruz, 59 miles from Rancagua de la Independencia Airport, offering a scenic retreat with mountain views. The property has received excellent user ratings for cleanliness and location, indicating a comfortable and well-maintained stay. This two-bedroom chalet, spanning 46 square metres, comfortably accommodates four guests. The property provides a range of amenities, including a swimming pool, jacuzzi, spa, and a fully equipped kitchen, as well as outdoor spaces like a terrace and garden, perfect for relaxation and enjoying the surrounding scenery.
Cabañas Tinycolchagua Cl - Santa Cruz
9.3 122 reviews

Cabañas Tinycolchagua Cl

house, Santa Cruz
The Cabañas y Padel Tiny Cabin is situated in Santa Cruz, O'Higgins region, about 60 miles from Rancagua de la Independencia Airport, offering a peaceful retreat in the heart of the region. Guest reviews consistently highlight the excellent location, cleanliness, and overall experience.
This compact one-bedroom cabin provides 26 square metres of space for up to one guest. It includes a private bathroom, air conditioning, a fully equipped kitchen, a terrace, a garden, free Wi-Fi, and free parking, ensuring a comfortable and convenient stay.
Casa Encino Ii - Santa Cruz
No reviews

Casa Encino Ii

house, Paniahue
This holiday cottage in Paniahue is located 187 kilometres from Santiago International Airport, offering a peaceful retreat for up to 11 guests.
This 130 square metre holiday home features two bedrooms, two bathrooms, a fully equipped kitchen, free Wi-Fi, private parking, and a terrace, with a flat-screen TV for entertainment and a strictly non-smoking policy.

Best pet friendly Santa Cruz vacation rentals

Among the 106 accommodations in Santa Cruz, here are the 4 best pet friendly rentals

Encantadora Cabaña Peumo - Santa Cruz
10 10 reviews

Encantadora Cabaña Peumo

cabin
This charming cabin is situated in the Santa Cruz countryside, just a short drive from the city centre and within easy reach of the famous boardwalk and beaches. The cabin has consistently received excellent ratings from previous guests for its cleanliness, location, and overall experience.
The cosy cabin can comfortably accommodate two guests and features a well-equipped kitchen with a fridge and microwave oven. Enjoy the beautiful views, relax in the jacuzzi, explore the surrounding area in a classic car, and take advantage of the many amenities, including a garden, parking, and internet access.
Casa Cálida Y Segura Con Jardín - Santa Cruz
9.7 12 reviews

Casa Cálida Y Segura Con Jardín

house
This three-bedroom, two-bathroom apartment in a peaceful Santa Cruz residential neighbourhood offers easy access to local supermarkets and public transport.
The two-storey property, sleeping up to six guests, features a private garden, gated entrance, and a wood-panelled living area, making it ideal for families or groups.
Cabañas Tiny Colchagua Cl - Santa Cruz
9.7 40 reviews

Cabañas Tiny Colchagua Cl

cabin
This house is located in a new development within Santa Cruz, offering complete social distancing and a peaceful, rural setting. It has received excellent ratings for user experience, location, and cleanliness.
The property is a one-bedroom, one-bathroom dwelling with a capacity of three guests. Amenities include a swimming pool, garden, parking, and a fully equipped kitchen with a fridge and microwave.
Tinny Loft House - Santa Cruz
10 1 review

Tinny Loft House

cabin
This secluded lodge in Santa Cruz offers a tranquil escape, located in a peaceful district ideal for relaxation.
This pet-friendly cabin accommodates up to three guests and features a kitchen, air conditioning, a swimming pool, jacuzzi, and sauna for a rejuvenating stay.
©2026 cozycozy.com