Compare vacation rentals in Cape Girardeau, MO from 100+ sites!

155 available vacation rental offers

7 nights
2
1
  • airbnb
  • booking
  • vrbo
  • expedia
  • sonder
  • priceline
  • tripadvisor
  • tripcom
  • homestay
  • hotelscom
  • orbitz
  • vacasa
Cape Girardeau, MO vacation rentals
Choose the perfect vacation accommodation
Price per night
Accommodation type
Rating

Best Vacation rentals and Airbnb offers in Cape Girardeau, MO

Best family friendly Cape Girardeau, MO vacation rentals

Among the 155 accommodations in Cape Girardeau, MO, here are the 4 best family friendly rentals

Visit The "Gone Girl" Neighborhood - Cape Girardeau, MO
9.7 175 reviews

Visit The "Gone Girl" Neighborhood

apartment, Cape Girardeau
This apartment is located in the "Gone Girl" filming district of Cape Girardeau, within walking distance of a park, school playground, and a short distance from both hospitals, the Cape Recreational trail, and a public golf course. It boasts excellent user, location, and cleanliness ratings.
This 1000 square foot dwelling has one bedroom and one bathroom. It includes a fully equipped kitchen, a spacious terrace or balcony, a garden, a spa, parking, and free amenities like bicycles and golf clubs.
Charming 3-bedroom House Near Downtown - Cape Girardeau, MO
10 4 reviews

Charming 3-bedroom House Near Downtown

apartment, Cape Girardeau
This Cape Girardeau vacation home is conveniently located within 1.2 miles of Isle Casino Cape Girardeau, Cape Rock Park, and Riverfront Park, and within 1.9 miles of the Show Me Center and Southeast Missouri State University.
This three-bedroom, three-bathroom house sleeps eight guests and offers a fully equipped kitchen, in-unit laundry, a playground, and a smoke-free environment, along with convenient parking and proximity to area attractions.
3 Bed Home - Deck & Fenced-in Back Yard - Sleeps 8 - Cape Girardeau, MO
9.7 73 reviews

3 Bed Home - Deck & Fenced-in Back Yard - Sleeps 8

apartment, Cape Girardeau
This centrally located apartment in Cape Girardeau is a few blocks from historic downtown and the SEMO campus, making it an excellent choice for travelers looking to explore the city. The apartment has received excellent ratings for its cleanliness, location, and user experience.
The apartment can accommodate up to 8 guests, with multiple sleeping areas, a family room, and a laundry area. It also features a large deck for outdoor relaxation and grilling, a fenced-in backyard for privacy and outdoor activities, and a fully equipped kitchen.
Historic Blvd District Home In Cape Girardeau - Cape Girardeau, MO
9.6 147 reviews

Historic Blvd District Home In Cape Girardeau

apartment, Cape Girardeau
This private apartment in Cape Girardeau's Historic Boulevard District offers a tranquil ambiance in a quiet neighborhood setting, within walking distance of SEMO University, Capaha Park, and the downtown riverfront. With excellent user, location, and cleanliness ratings, this apartment provides a comfortable and convenient stay for up to 6 guests.
Featuring a spacious layout with 2 bedrooms, 1 bathroom, and a fully equipped kitchen, this apartment provides ample space and amenities for a comfortable self-catering experience. Guests can enjoy the outdoors on the large front porch or relax in the garden, while the air conditioning ensures a pleasant indoor environment.

Best pet friendly Cape Girardeau, MO vacation rentals

Among the 155 accommodations in Cape Girardeau, MO, here are the 4 best pet friendly rentals

Log Cabin W/ Hot Tub - Near Casino & Downtown Cape - Cape Girardeau, MO
9.8 314 reviews

Log Cabin W/ Hot Tub - Near Casino & Downtown Cape

cabin, Cape Girardeau
This cozy cabin is located in a residential area on the edge of Cape Girardeau, just a short drive from the casino, country club, and downtown. It has received excellent ratings for location, cleanliness, and user experience.
The cabin comfortably sleeps four guests in one bedroom and a living room with a pull-out queen-size bed. It features a full kitchen, a hot tub, a large deck with a fire pit, and entertainment options like a pool table, darts, and board games.
Riverfront Grey House - Cape Girardeau, MO
9.3 8 reviews

Riverfront Grey House

apartment, Cape Girardeau
This two-bedroom rental unit offers prime Mississippi River views from a private deck and is located a short drive from downtown Cape Girardeau attractions, within walking distance of the local casino.
This newly remodeled apartment accommodates up to four guests and features a dedicated workspace, fast WiFi, air conditioning, a full kitchen, and a luxurious memory foam mattress.
Euro Style Tiny Home With Deck - Cape Girardeau, MO
9.8 24 reviews

Euro Style Tiny Home With Deck

cabin, Cape Girardeau
This Euro-style tiny home is located near Boutin Creek and natural rock formations, offering a secluded natural setting in Cape Girardeau.
This accessible 2-bedroom, 1-bathroom cottage accommodates up to 3 guests and features a kitchenette with a fridge and microwave, air conditioning, garden, parking, and internet, providing a unique tiny home village experience.
Brand New 2 Bedroom Unit Right In Downtown Cape. - Cape Girardeau, MO
9.9 319 reviews

Brand New 2 Bedroom Unit Right In Downtown Cape.

apartment, Cape Girardeau
This apartment is located in downtown Cape Girardeau, just steps away from restaurants, the riverfront, and nightlife, offering a lively atmosphere. It has received excellent ratings for location, cleanliness, and overall user experience.
This rental offers two bedrooms and can comfortably accommodate up to four guests. It includes a fully equipped kitchen, laundry facilities, a deck, private parking, and entertainment options like a smart TV, board games, and a dog bed and bowls.

Frequently Asked Questions about vacation rentals in Cape Girardeau, MO

  • What are the must-see sights in Cape Girardeau, Missouri?

    For must-see sights in Cape Girardeau, you definitely want to check out the historic downtown area, with its charming architecture and unique shops. The Southeast Missouri State University campus is also worth a stroll, especially around the beautiful riverfront. And of course, you can't miss the impressive River Campus, home to the impressive Kent Library and several other university buildings. For a dose of history, the William J. Harrison House Museum offers a glimpse into the city's past.
  • What are the best Airbnb and vacation rentals in Cape Girardeau, MO?

    The Cabin In Eden, Downtown Guesthouse- Romantic Getaway and Unique Design | Walk Downtown/river | -5 Mile Semo are the most popular Airbnb and vacation rentals in Cape Girardeau, MO among travelers.

  • Are there unique natural phenomena in Cape Girardeau, Missouri?

    While Cape Girardeau doesn't have dramatic natural phenomena like geysers or massive canyons, its location on the Mississippi River provides stunning river views and opportunities for bird watching. The river itself is a natural wonder, and the bluffs along the river offer scenic overlooks. Exploring the nearby forests and trails offers a chance to experience the natural beauty of the region.
  • What are the most popular Airbnbs in Cape Girardeau, MO?

    Among the Airbnbs in Cape Girardeau, MO, The Cabin In Eden, Downtown Guesthouse- Romantic Getaway and Unique Design | Walk Downtown/river | -5 Mile Semo are the most popular ones.

  • What essentials should you bring along for a trip to Cape Girardeau, Missouri?

    Pack comfortable walking shoes, as you'll likely be doing a lot of exploring on foot. Depending on the time of year, you'll want layers of clothing, as the weather can be unpredictable. Sunscreen, a hat, and sunglasses are essential, especially during the summer months. Don't forget your camera to capture the beautiful scenery and charming architecture.
  • What are the best vacation rentals with a pool in Cape Girardeau, MO?

  • What famous events or festivals are happening in Cape Girardeau, Missouri?

    Cape Girardeau hosts several events throughout the year. The Fall Festival is a popular event that features local crafts, food, and entertainment. The Christmas parade is another community favorite. Check local event listings closer to your travel dates for the most up-to-date information on specific events and festivals.
  • What are the best rentals for families and kids in Cape Girardeau, MO?

  • What is the average daily budget you should plan for (accommodation, food, transportation, activities) in Cape Girardeau, Missouri?

    A daily budget of $150-$300 per person should comfortably cover accommodation, meals, local transportation (consider walking or using ride-sharing services), and entry fees for attractions. This is just an estimate, and your actual spending will depend on your choices and preferences.
  • What are the best rentals or Airbnbs with a jacuzzi in Cape Girardeau, MO?

  • Where can you find the best restaurants serving local dishes in Cape Girardeau, Missouri, and what are the must-try specialties?

    There are many great restaurants in Cape Girardeau. For a taste of local flavors, try a restaurant specializing in Southern comfort food. Many establishments feature barbecue, catfish, and other regional specialties. Checking local reviews and guides will help you discover hidden gems and popular choices.
  • What are some less-famous attractions in Cape Girardeau, Missouri that are worth the visit?

    The Riverfront Park offers a relaxing spot to enjoy the Mississippi River. The Trail of Tears State Park, a short drive from Cape Girardeau, provides a somber but important historical experience. Exploring the smaller, independent shops and art galleries in the downtown area can reveal unique finds and local artistry.
  • What are the best activities for engaging with locals and understanding their culture in Cape Girardeau, Missouri?

    Strolling through the historic downtown area and chatting with shop owners is a great way to connect with locals. Attending a local event or festival is another opportunity to experience the community's spirit. Visiting the Southeast Missouri State University campus provides a chance to interact with students and faculty.
  • What unique natural landscapes and terrain features can travelers explore in and around Cape Girardeau, Missouri?

    The Mississippi River is the defining natural feature, offering scenic views and recreational opportunities. The bluffs along the river create a dramatic landscape. Exploring the nearby forests and hiking trails provides a chance to experience the diverse natural beauty of the region.
  • How many days are ideal for visiting Cape Girardeau, Missouri, and what are some itinerary suggestions?

    Two to three days is a good amount of time to explore Cape Girardeau at a relaxed pace. A possible itinerary could include exploring the historic downtown area on day one, visiting the River Campus and Southeast Missouri State University on day two, and enjoying outdoor activities or exploring nearby attractions like Trail of Tears State Park on day three. This is just a suggestion; tailor it to your interests.

Nearby regions

Best Cape Girardeau, MO vacation rentals with a pool

Among the 155 accommodations in Cape Girardeau, MO, here are the 1 best rentals with a pool

Cozy Cape Girardeau Loft - Cape Girardeau, MO
No reviews

Cozy Cape Girardeau Loft

apartment, Cape Girardeau
This upper-unit duplex in Cape Girardeau offers proximity to local hospitals, downtown businesses, and shopping areas, with the exact location minutes from these points of interest.
This one-bedroom, one-bathroom apartment accommodates two guests and features a king-size bed, a fully equipped kitchen with a large refrigerator, in-unit laundry, off-street parking, and a Smart TV, making it ideal for extended stays.

Best Cape Girardeau, MO vacation rentals with parking

Romantic Tea Cottage With Deck And Nature - Cape Girardeau, MO
8.0 1 review

Romantic Tea Cottage With Deck And Nature

resort, Cape Girardeau
This Romantic Tea Cottage With Deck And Nature is located in Cape Girardeau, 8.7 miles from the regional airport.
This 380 square feet cottage accommodates up to 7 guests and features 1 bedroom, 1 bathroom, air conditioning, internet, a kitchenette, a living room with a fireplace, and a private deck within a tranquil garden setting.
Private Nurse Retreat 2br-1ba - Cape Girardeau, MO
9.0 2 reviews

Private Nurse Retreat 2br-1ba

apartment, Cape Girardeau
This two-bedroom apartment near Mercy Hospital in Cape Girardeau offers easy access to Capaha Park, SEMO's Houck Field House, and local restaurants.
The unit sleeps four guests and includes a full kitchen, air conditioning, parking, and internet access; nearby attractions include the Cape Catfish baseball field.
Downtown Cape 2 Bdrm/2 Bath Apt | Cozy & Walkable - Cape Girardeau, MO
9.7 81 reviews

Downtown Cape 2 Bdrm/2 Bath Apt | Cozy & Walkable

apartment, Cape Girardeau
This downtown Cape Girardeau apartment offers a convenient location, steps from restaurants, bars, and shops, with easy access to walking trails and parks.
The two-bedroom, two-bathroom unit sleeps five guests comfortably and includes a fully equipped kitchen, in-unit laundry, free parking, and a dedicated workspace with high-speed Wi-Fi.
Beautiful Historic Boulevard District Apartment - Cape Girardeau, MO
10 468 reviews

Beautiful Historic Boulevard District Apartment

apartment, Cape Girardeau
This 2-bedroom apartment is located in Cape Girardeau's Historic Boulevard District, just a short walk from SEMO University, Capaha Park, and the downtown riverfront. Guests have consistently rated the apartment excellent for its cleanliness, location, and overall experience.
The apartment comfortably accommodates up to 4 guests and features a private front porch with a swing and sitting area. Amenities include a fully equipped kitchen, laundry facilities, air conditioning, and off-street parking.
©2026 cozycozy.com