Compare vacation rentals in Santee, SC from 100+ sites!

21 available vacation rental offers

7 nights
2
1
  • airbnb
  • booking
  • vrbo
  • expedia
  • sonder
  • priceline
  • tripadvisor
  • tripcom
  • homestay
  • hotelscom
  • orbitz
  • vacasa
Santee, SC vacation rentals
Choose the perfect vacation accommodation
Price per night
Accommodation type
Rating

Best Vacation rentals and Airbnb offers in Santee, SC

Choose the Right Family-Friendly Vacation Rentals in Santee, SC

The right family vacation rental in Santee, SC makes all the difference, keeping you close to top city attractions.

Lake Marion - Majestic Big Water View! - Santee, SC
10 12 reviews
Santee, SC
08/25 – 08/28
$299/nighttotal: $897 (3 )

Lake Marion - Majestic Big Water View!

2 4
apartment , Santee
This Santee condo rental is conveniently located within three miles of Santee Cooper Country Club, Santee Outlets, Santee National Golf Club, Santee Town Hall, and Santee State Park.
This two-bedroom, two-bathroom unit sleeps six guests and offers a fully equipped kitchen, in-unit laundry, free WiFi, a jetted tub, and access to a community pool, jacuzzi, and barbecue grills.
Pet-friendly Lake Marion Getaway - Just Off I-95! - Santee, SC
9.9 181 reviews
Santee, SC
08/14 – 08/20
$188/nighttotal: $1128 (6 )

Pet-friendly Lake Marion Getaway - Just Off I-95!

1 2
apartment , Santee
This Santee apartment is a perfect accommodation for families seeking a comfortable and convenient stay. It has received excellent ratings for its location, cleanliness, and user experience.
The apartment features three bedrooms, two bathrooms, and a guest capacity of seven. It comes fully equipped with a kitchen, air conditioning, a garden, parking, and high-speed internet. Pets are also welcome, making it an ideal choice for those traveling with furry companions.
Lake Marion "Penthouse" At Club Wyndham Resort - Santee, SC
9.9 31 reviews
Santee, SC
08/25 – 08/28
$198/nighttotal: $594 (3 )

Lake Marion "Penthouse" At Club Wyndham Resort

2 4
apartment , Santee
This Santee apartment is situated near a lake with a marina, just a 1.25-hour drive from Charleston and Columbia, offering a peaceful retreat with stunning lake views. The surrounding area boasts a mix of natural beauty and charming small towns with local restaurants and shops.
The apartment comfortably accommodates up to 8 guests with 2 bedrooms and 1 bathroom. It features a fully equipped kitchen, air conditioning, a swimming pool, a garden, a fitness center, and parking. Enjoy resort amenities like grilling, volleyball, ping pong, and movie nights, as well as access to nearby golf courses, a waterpark, and Santee State Park & Wildlife Preserve.
Enjoy Your Day On The Lake!  Direct Access W/dock - Santee, SC
Santee, SC
07/15 – 10/01
$269/nighttotal: $20982 (78 )

Enjoy Your Day On The Lake! Direct Access W/dock

1 1
house , Santee
This Santee house rental, perfect for families, offers one bedroom and one bathroom, sleeping up to four guests, and includes amenities such as a swimming pool, Wi-Fi, and a kitchen equipped with a refrigerator, microwave, and dishwasher.
Further details regarding the precise location within Santee and proximity to local attractions are needed to complete the description.

Best Santee, SC vacation rentals with parking

2 Mi To Lake Marion! Pet-friendly Home W/ Yard - Santee, SC
10 1 review
Santee, SC
07/08 – 07/22
$198/nighttotal: $2772 (14 )

2 Mi To Lake Marion! Pet-friendly Home W/ Yard

2 2
apartment , Santee
This Santee vacation rental is located 2 miles from Santee State Park and Lake Marion, providing easy access to outdoor recreation and golf.
This 900 square foot, 2-bedroom, 2-bathroom house accommodates up to 4 guests and features a full kitchen, central air conditioning, a covered deck, and a fenced yard, with nearby attractions including multiple golf courses and guided fishing tours.
Lakefront Retreat On Lake Marion  Perfect For Fishing & Relaxation - Santee, SC
10 3 reviews
Santee, SC
08/25 – 08/28
$260/nighttotal: $780 (3 )

Lakefront Retreat On Lake Marion Perfect For Fishing & Relaxation

2 4
apartment , Santee
This two-bedroom condo offers a prime waterfront location on Lake Marion in Santee, SC, with direct access and a boat slip, just under 1 mile from Santee Cooper Country Club and Santee National Golf Club. Enjoy a fully stocked kitchen, arcade games, and board games, with a guest capacity of 5, perfect for families and fishermen visiting Santee.
The Tee Vee Cove Is The Place To Be Located Near Great Golfing, Fishing And Food - Santee, SC
9.0 2 reviews
Santee, SC
07/15 – 10/01
$136/nighttotal: $10608 (78 )

The Tee Vee Cove Is The Place To Be Located Near Great Golfing, Fishing And Food

2 1
apartment , Elloree
This Elloree house is located in a district offering convenient access to the South Carolina State College Historic District and Edisto Memorial Gardens, with Santee State Park and Santee National Wildlife Refuge also within easy reach.
This two-bedroom, two-bathroom apartment accommodates up to six guests and features air conditioning, heating, internet, a garden, and parking.
Sunny Santee Stay | 3br Retreat Near Lake & Golf - Santee, SC
10 7 reviews
Santee, SC
08/25 – 08/28
$291/nighttotal: $873 (3 )

Sunny Santee Stay | 3br Retreat Near Lake & Golf

3 4
apartment , Santee
This Santee, South Carolina apartment offers convenient access to Lake Marion and nearby golf courses, providing a relaxing base for exploring the area. This three-bedroom, two-bathroom rental sleeps six, features a fully equipped kitchen with appliances including an air fryer and dishwasher, and provides easy self check-in.

Frequently Asked Questions about vacation rentals in Santee, SC

Destinations nearby

Guest-Favorite Vacation Rentals with a Terrace in Santee, SC

Enjoy your own private terrace with city skyline views at these vacation rentals in Santee, SC.

Club Wyndham Lake Marion - Santee, SC
10 3 reviews
Santee, SC
08/25 – 08/28
$153/nighttotal: $459 (3 )

Club Wyndham Lake Marion

2 4
resort , Santee
Club Wyndham Lake Marion, a budget-friendly hotel in Poinciana's Highland Park neighborhood, is located approximately 14 miles from Orlando's city center and near Disney's Hollywood Studios, Animal Kingdom, and Epcot.
This one-bathroom vacation rental sleeps two guests and offers proximity to Orlando theme parks; further amenities and details require additional inquiry.
Waterfront Condo On Lake Marion - Santee, SC
10 7 reviews
Santee, SC
07/08 – 07/22
$450/nighttotal: $6300 (14 )

Waterfront Condo On Lake Marion

3 2
resort , Santee
This Santee apartment is located near a golf course and lake, just an 11-minute walk from Lake Marion and a short drive from Santee State Park, offering easy access to both nature and leisure activities. The apartment spans 1700 square feet and comfortably accommodates up to 6 guests with 3 bedrooms and 3 bathrooms.
This Santee rental provides a fully equipped kitchen, a washer and dryer, a barbecue grill, and a swimming pool and jacuzzi. Guests can enjoy the on-site parking, high-speed internet, and a connected TV while enjoying the beautiful Santee weather.
Lakeside Vacationing Close To Golf Courses, Restaurants And Boat Rental Company! - Santee, SC
9.2 10 reviews
Santee, SC
08/14 – 08/20
$328/nighttotal: $1968 (6 )

Lakeside Vacationing Close To Golf Courses, Restaurants And Boat Rental Company!

3 2
apartment , Santee
This 3-bedroom, 3-bathroom apartment is located in Santee, South Carolina, just minutes from Santee Cooper Country Club and Santee National Golf Club, and about 30 feet from a pool overlooking Lake Marion, the largest lake in South Carolina. The apartment offers a private boat landing and dock, perfect for those who enjoy bringing their own boats, and is close to Santee National Wildlife Refuge and Santee State Park for nature exploration and outdoor activities.

Neighborhoods and points of interest in Santee, SC

Top-Rated Pet-Friendly Vacation Rentals in Santee, SC

Discover dog-friendly vacation rentals in Santee, SC situated perfectly for city walks and nearby dog parks.

Viridian Retreat - Santee, SC
Santee, SC
08/25 – 08/28
$336/nighttotal: $1008 (3 )

Viridian Retreat

1 4
apartment , Santee
This Santee ranch-style house is located adjacent to the Santee Cooper Golf Course and is a short drive from Lake Marion, offering prime access for golf and water activities.
This pet-friendly rental accommodates up to eight guests with three bedrooms and two bathrooms, featuring a kitchen with a fridge and dishwasher, air conditioning, a garden with a grill and patio set, and parking.
Lake Marion - Majestic Big Water Views - Santee, SC
9.8 21 reviews
Santee, SC
07/29 – 08/12
$229/nighttotal: $3206 (14 )

Lake Marion - Majestic Big Water Views

1 1
apartment , Santee
This ground floor condo is located on the shores of Lake Marion, offering stunning water views and easy access to boating and fishing. The property is also conveniently close to Santee State Park and the Palmetto Trail, providing ample opportunities for outdoor recreation. This two-bedroom, two-bathroom apartment comfortably accommodates up to six guests. The condo features a kitchen, air conditioning, a swimming pool, and parking, as well as internet access, making it an ideal choice for families and groups looking for a relaxing and enjoyable vacation.
Dockside Villa Lake Marion - Santee, SC
9.6 27 reviews
Santee, SC
08/05 – 08/08
$180/nighttotal: $540 (3 )

Dockside Villa Lake Marion

1 2
apartment , Santee
This two-bedroom, two-bathroom apartment is located on Lake Marion in Santee, South Carolina, a short distance from three world-class golf courses and within walking distance of a boat landing and boat rental. The apartment comfortably sleeps six guests and features a private balcony with exceptional views of the lake, a boat slip, and access to on-site amenities like outdoor grills, walking trails, and picnic tables.
Lakefront Lookout - Santee, SC
9.8 76 reviews
Santee, SC
07/08 – 07/22
$202/nighttotal: $2828 (14 )

Lakefront Lookout

1 2
apartment , Santee
This Santee apartment offers stunning views of Lake Marion and is conveniently located near the pedestrian bridge and the lakefront. It consistently receives excellent ratings for its location, cleanliness, and overall experience.
The apartment features two bedrooms and two bathrooms, comfortably accommodating up to six guests. Enjoy a fully equipped kitchen, a relaxing atmosphere, and access to amenities like a swimming pool, a garden, and boat and trailer parking.
©2026 cozycozy.com