Compare vacation rentals in Seneca, SC from 100+ sites!
58 available vacation rental offers
Choose the perfect vacation accommodation
Price per night
Accommodation type
Rating
Best Vacation rentals and Airbnb offers in Seneca, SC
9.8 73 reviews
Seneca, SC
07/16 – 07/20
$175/nighttotal: $700 (4 )
Cozy Cottage Quiet And Secluded But Close To Everything.
1 3
cottage , Seneca
This waterfront cabin is located near Seneca, South Carolina, just 15 kilometers from three popular lakes: Lake Keowee, Keowee Reservoir, and Lake Hartwell. Guests have consistently rated this property excellent for its location, cleanliness, and overall experience. The two-bedroom cabin can comfortably accommodate up to five guests. Enjoy modern amenities like free Wi-Fi, a Smart TV, and a fully equipped kitchenette, along with outdoor features like a garden and barbecue grills.
10 128 reviews
Seneca, SC
07/16 – 07/20
$242/nighttotal: $968 (4 )
The Cottage
1 3
apartment , Walhalla
This charming cottage is located near Walhalla, South Carolina, just a short drive from Walmart, Oconee Memorial Hospital, and Clemson University. It has consistently received excellent ratings for its cleanliness, location, and overall experience. The cottage offers one bedroom and one bathroom, comfortably accommodating up to four guests. You'll enjoy a fully equipped kitchen, air conditioning, a private garden, and a peaceful fishing pond on the property.
9.6 9 reviews
Seneca, SC
07/16 – 07/20
$333/nighttotal: $1332 (4 )
3 Bedroom 2 Bath Home Located Minutes From Keowee Mariana, Shopping And Clemson
3 3
apartment , Seneca
This Seneca vacation rental, near Lake Keowee and a short walk from the marina, offers easy access to downtown Seneca and is a 20-minute drive from Clemson University. This 1600-square-foot home features three bedrooms, two bathrooms, sleeps six, and includes a fully equipped kitchen, air conditioning, a garden, tennis court, parking, and on-site game room.
10 1 review
Seneca, SC
06/23 – 07/23
$213/nighttotal: $6390 (30 )
Tiny Retreat With Boat Dock, Lake Hartwell ,Ga
1 1
apartment , Gumlog
This waterfront tiny home in Martin, Georgia, offers direct access to Lake Hartwell with a private boat dock, situated only a few hundred yards from a public boat ramp. This cozy 1-bedroom, 1-bathroom dwelling spans 580 square feet and accommodates up to two guests, featuring a kitchen with a fridge and microwave, air conditioning, WiFi, a smart TV, and a terrace or balcony on a 0.34-acre lot, with a dog-friendly policy for one dog under 20 lbs for an additional fee.
10 10 reviews
Seneca, SC
07/16 – 07/20
$214/nighttotal: $856 (4 )
Game Day Base – Seneca Townhome Near Clemson
1 3
apartment , Seneca
This two-bedroom, two-bathroom townhome is located in Seneca, South Carolina, minutes from downtown Seneca and a short drive to Clemson University and Clemson Memorial Stadium. The single-story property offers a fully equipped kitchen, in-unit laundry, a private patio, free driveway parking, and comfortably accommodates four guests, with easy access to Lake Hartwell and Lake Keowee.
9.8 25 reviews
Seneca, SC
07/16 – 07/20
$157/nighttotal: $628 (4 )
Historic Seneca Bungalow
2 3
apartment , Seneca
This charming bungalow is located in downtown Seneca, just two blocks from Ram Cat Alley, a bustling shopping and dining district, and a 10-minute drive from Clemson University's stadium. This well-rated home is perfect for families or small groups looking for a peaceful retreat. This cozy cottage has two bedrooms and one bathroom, comfortably accommodating up to four guests. Enjoy modern amenities like air conditioning, internet, and a fully equipped kitchen, as well as a peaceful garden and easy access to nearby lakes for swimming, boating, and fishing.
10 1 review
Seneca, SC
07/16 – 07/20
$290/nighttotal: $1160 (4 )
The Landing Spot
3 3
house , Seneca
This Seneca vacation home, seven miles from Clemson Memorial Stadium and 48 miles from Greenville-Spartanburg International Airport, offers convenient access to local attractions. The 1600-square-foot house features three bedrooms, two bathrooms, sleeps eleven guests, and includes amenities such as a fully equipped kitchen, private balcony, table tennis, outdoor fireplace, free Wi-Fi, and free private parking.
9.9 27 reviews
Seneca, SC
07/16 – 07/20
$286/nighttotal: $1144 (4 )
Quin's Lake House, Keowee.
Private Bottom Floor.
1 3
house , Seneca
This Seneca, South Carolina rental is located 7.6 miles from Clemson University's main campus, offering easy access to campus events and activities. This two-story house features two bedrooms (one king, one with extra-long twin beds), one bathroom, a spacious gathering room with a shuffleboard table and putting green, a private lower-level entrance, and kayaks for guest use, accommodating up to four guests.
10 4 reviews
Seneca, SC
07/16 – 07/20
$254/nighttotal: $1016 (4 )
Hidden Cove Cottage - With Lake Access
1 3
cabin , Seneca
This secluded lakeside cottage is located in a private wooded cove, offering easy shoreline access and is just minutes from Clemson University and Memorial Stadium. This cabin accommodates up to 6 guests and features a spacious deck with outdoor seating, a BBQ grill, fire pit, well-equipped kitchen, and reliable Wi-Fi.
10 13 reviews
Seneca, SC
07/16 – 07/20
$328/nighttotal: $1312 (4 )
Oak Valley Hideaway
1 3
cabin , Seneca
This Seneca, South Carolina cabin offers a secluded retreat amidst trees and open fields, providing stunning wildlife views. The 2-bedroom, 2-bathroom house sleeps 4 guests and features a kitchen with a fridge, microwave, and dishwasher; a hot tub; a fireplace; and a fire pit, perfect for enjoying the outdoors.
10 44 reviews
Seneca, SC
07/16 – 07/20
$217/nighttotal: $868 (4 )
One Particular Cove ... On Lake Hartwell
1 3
house , Seneca
This Seneca lakefront apartment is located just 5 minutes from Friendship Boat Landing and 20 minutes from Clemson and Anderson, making it a convenient base for exploring the area. It has consistently received excellent ratings for its cleanliness, location, and overall experience. This 2-bedroom apartment comfortably accommodates 4 guests and features a fully equipped kitchen, a spacious living area, and a private patio with a fire pit and dock. Enjoy fishing, swimming, boating, or simply relaxing by the lake with amenities like a gas grill, high-speed internet, and entertainment options like a smart TV and Nintendo Switch.
10 106 reviews
Seneca, SC
07/16 – 07/20
$141/nighttotal: $564 (4 )
Oak Hill Getaway
1 3
cabin , Seneca
This Seneca house rental is centrally located between Seneca and Clemson, SC, a five-minute drive from Ram Cat Alley and ten minutes from Clemson University, offering easy access to lakes, hiking trails, and local attractions. This one-bedroom, one-bathroom dwelling sleeps six guests and boasts amenities including air conditioning, internet, parking, and a full kitchen; enjoy nearby water activities on Lakes Jocassee, Keowee, and Hartwell.
Our Favorite Family-Friendly Vacation Rentals in Seneca, SC
These kid-friendly vacation rentals in Seneca, SC keep you close to top city attractions for a stress-free family vacation.
9.8 44 reviews
Seneca, SC
07/16 – 07/20
$313/nighttotal: $1252 (4 )
Lakefront Escape
1 3
apartment , Utica
This lake house rental near Clemson, South Carolina, is located seven miles from Clemson University and offers direct access to Lake Hartwell. Sleeping 10-12 guests in four separate sleeping areas, this three-bedroom, three-bathroom home boasts a large deck overlooking Lake Hartwell, a basement living space, ample parking for cars and boat trailers, and a fully equipped kitchen including a dishwasher.
9.5 17 reviews
Seneca, SC
07/16 – 07/20
$1336/nighttotal: $5344 (4 )
New! Lakefront Seneca Hideaway W/ Fire Pit & Decks
1 3
apartment , Seneca
This Seneca lakefront home, located on Lake Hartwell, offers a 20-minute boat ride to Clemson and Portman Marinas. The five-bedroom, three-bathroom house sleeps fourteen guests and boasts a chef's kitchen, private hot tub, boat dock with two slips, kayaks, and ample outdoor amenities including a screened porch, fire pit, and multiple decks.
9.8 7 reviews
Seneca, SC
07/16 – 07/20
$815/nighttotal: $3260 (4 )
Family Seneca Stay - 4mi To Clemson Memorial Stadium
3 3
apartment , Newry
This Seneca, South Carolina vacation rental is located in a rural area near Lake Hartwell and Lake Keowee, providing easy access to Clemson University and its Memorial Stadium. This three-bedroom, three-bathroom home features a spacious split-level layout, accommodating up to 10 guests and offering amenities such as a fully equipped kitchen with dishwasher, air conditioning, and a private garden with parking; nearby attractions include the South Carolina Botanical Gardens and Littlejohn Coliseum.
9.8 51 reviews
Seneca, SC
07/16 – 07/20
$190/nighttotal: $760 (4 )
The Clemson Cottage
1 3
apartment , Utica
This upstate cottage in Utica offers a tranquil porch for relaxation and is conveniently located a short drive to Clemson, with ride-share availability for exploring nearby lakes, trails, waterfalls, and mountains. This family-friendly rental accommodates up to 6 guests with 3 bedrooms and 2 full bathrooms, featuring a kitchen with a fridge, microwave, and dishwasher, plus air conditioning, a garden, front and rear patios, and private parking, all within walking distance to a store and gas station.
Best Seneca, SC vacation rentals with parking
10 3 reviews
Seneca, SC
07/16 – 07/20
$455/nighttotal: $1820 (4 )
Cozy Downtown Seneca Bungalow
3 3
house , Seneca
This Seneca bungalow is located just 7.8 miles from Clemson Memorial Stadium, offering a convenient base for exploring the area. The charming downtown location provides easy access to local shops, restaurants, and attractions. This 1000 square foot house has three bedrooms and two bathrooms, comfortably accommodating up to 15 guests. Enjoy amenities like a fully equipped kitchen, private parking, a washing machine, and free Wi-Fi, making this a great choice for families or groups.
10 19 reviews
Seneca, SC
07/16 – 07/20
$405/nighttotal: $1620 (4 )
Renovated Bungalow 1 Block From Downtown Seneca! 7 Miles From Clemson!
3 3
apartment , Seneca
This family-friendly bungalow is located in downtown Seneca, just a short drive from both Lake Keowee and Lake Hartwell. You'll be close to the area's natural beauty and popular attractions like the South Carolina Botanical Gardens and the Little John Coliseum. The 3-bedroom, 2-bathroom home offers comfortable accommodations for up to 6 guests. It features amenities like air conditioning, free Wi-Fi, a barbecue, a washer and dryer, a fully equipped kitchen, and a smart TV.
Seneca, SC
07/16 – 07/20
$358/nighttotal: $1432 (4 )
Lake Keowee Gem! Close To Clemson & Hiking Trails
2 3
house , Newry
This vacation home is located in a district offering lake views, approximately 11 miles from Clemson Memorial Stadium and 47 miles from Greenville-Spartanburg International Airport. This 1800 sq ft house accommodates 11 guests with 2 bedrooms, 2 bathrooms, a full kitchen, air conditioning, a terrace, and garden, with free Wi-Fi and parking available.
9.0 4 reviews
Seneca, SC
06/23 – 07/23
$313/nighttotal: $9390 (30 )
Keowee Sc Lake Home
3 1
apartment , West Union
This house is located in West Union, South Carolina, just a short drive from restaurants, bars, the Tiki Hut, the Light House, Clemson's football stadium, and the South Carolina Botanical Gardens. This lakefront property has received excellent reviews from previous guests. This vacation home has three bedrooms and two bathrooms, accommodating up to six guests. Guests can enjoy a microwave, dishwasher, air conditioning, a jacuzzi, and a covered dock with direct access to the lake.
Frequently Asked Questions about vacation rentals in Seneca, SC
Which walking or cycling routes are the best in Seneca, SC?
For a leisurely walk or bike ride, the Seneca Greenway Trail is a great choice. It runs along the Seneca River and offers beautiful views of the surrounding area. If you're looking for a more challenging route, the Foothills Trail offers scenic hiking and mountain biking opportunities.
What are the best Airbnb and vacation rentals in Seneca, SC?
What sports or outdoor activites can visitors enjoy in and around Seneca, SC?
Seneca is a great place for outdoor enthusiasts! You can go fishing, boating, or kayaking on Lake Keowee, play a round of golf at one of the local courses, or hike or bike on the many trails in the area. There are several parks, like the beautiful Gant Park, that are great for picnics and relaxing.
What other towns or cities can be easily accessed from Seneca, SC?
Seneca is conveniently located near several other towns and cities. You can easily drive to Clemson, Greenville, and Anderson, all within a 30-minute drive. If you want to explore further, you can visit Charleston or Columbia, both within a 2-hour drive.
What are the best vacation rentals with a pool in Seneca, SC?
What amenities are commonly available in vacation rentals in Seneca, SC?
Vacation rentals in Seneca typically offer a range of amenities, including kitchens, laundry facilities, and outdoor spaces like patios or decks. Many also have access to swimming pools, hot tubs, and fire pits. Some places even have boat docks if you're planning to enjoy the lake.
What are the best rentals for families and kids in Seneca, SC?
What time of year is best to rent a vacation rental Seneca, SC?
The best time to visit Seneca depends on your preferences. Spring and fall offer mild temperatures and beautiful scenery, while summer is great for water activities on Lake Keowee. If you enjoy the cooler weather, you can visit in the winter, but keep in mind that some outdoor activities may be limited.
What are the best rentals or Airbnbs with a jacuzzi in Seneca, SC?
Find the Best Vacation Rentals with Balconies in Seneca, SC
Enjoy a Seneca, SC vacation rental with a balcony and stunning city skyline views for a truly memorable stay.
9.5 27 reviews
Seneca, SC
07/16 – 07/20
$481/nighttotal: $1924 (4 )
North Forty Family Friendly Home
4 3
apartment , Newry
This Newry waterfront vacation home offers stunning Lake Keowee views, less than a mile from the lake and nine miles from Keowee Key Golf Course and High Falls County Park. This four-bedroom, two-bathroom house sleeps eight guests and includes a fully equipped kitchen, laundry facilities, a balcony, and on-site barbecue grills; enjoy swimming, boating, fishing, and golfing nearby.
9.0 2 reviews
Seneca, SC
07/16 – 07/20
$292/nighttotal: $1168 (4 )
Cozy Seneca Getaway Pet Friendly Sleeps 7!
3 3
apartment , Seneca
This pet-friendly vacation home in Seneca offers prime lakeside living, situated a 5-minute walk from Lake Keowee and a 14-minute walk from South Cove Park. This 1570 sq ft rental features 3 bedrooms, 3 bathrooms, and accommodates up to 7 guests, boasting a balcony, a fully equipped kitchen, air conditioning, and Wi-Fi, with proximity to Cross Creek Plantation Golf and Memorial Stadium.
9.6 11 reviews
Seneca, SC
07/16 – 07/20
$576/nighttotal: $2304 (4 )
New! Beautiful 5 Bedroom Lake Keowee Cove Home!
5 3
apartment , Seneca
This Indian Oaks vacation home sits steps from Lake Keowee, within 3 miles of South Cove Park and Oconee Memorial Hospital, and close to Applewood Shopping Center. This 5-bedroom, 3-bathroom house sleeps 10 guests and boasts a fully equipped kitchen, jacuzzi, tennis court, and on-site amenities including an arcade and barbecue grills, providing easy access to water activities and nearby attractions.
8.0 2 reviews
Seneca, SC
07/16 – 07/20
$523/nighttotal: $2092 (4 )
New! The Tiger's Perch- Close To Clemson.
4 3
apartment , Seneca
This Seneca lakeside rental is minutes from Lake Keowee and a short drive from Blue Ridge Field, offering easy access to outdoor recreation and local attractions like The Gauntlet and Oconee Community Theatre. This four-bedroom, two-bathroom apartment sleeps eight guests and features a fully equipped kitchen, in-unit laundry, Wi-Fi, a balcony, and a garden, providing comfortable accommodations for families or groups visiting Seneca, South Carolina.
Top Dog-Friendly Vacation Rentals in Seneca, SC
Traveling with pets? These dog-friendly vacation rentals and Airbnbs in Seneca, SC are steps away from dog parks and city walks.
Seneca, SC
06/23 – 07/23
$133/nighttotal: $3990 (30 )
Blacksheep Off Grid Cabin #1
1 1
cabin , Walhalla
This off-grid woodland retreat is located less than 10 miles from Walhalla, the Gateway to the Blue Ridge Mountains, offering absolute privacy deep in the woods. This cabin accommodates two guests and features air conditioning, a private creek, a modern outdoor shower with hot water, and a TV with a DVD player, with basic power provided by a generator.
9.8 8 reviews
Seneca, SC
07/16 – 07/20
$278/nighttotal: $1112 (4 )
8 Mi To Clemson: Peaceful Family Home W/ Yard
3 3
apartment , Seneca
This Seneca vacation rental is a 12-minute walk from the Shaver Recreation Complex and a 5-minute drive from Lake Keowee, offering easy access to outdoor recreation. The 1400-square-foot apartment sleeps six guests and features three bedrooms, two bathrooms, a fully equipped kitchen with modern appliances, in-unit laundry, a private garden, and parking.
Seneca, SC
07/16 – 07/20
$377/nighttotal: $1508 (4 )
Lake Keowee Gem! Close To Clemson & Hiking Trails
2 3
apartment , Newry
This Lake Keowee condo in Seneca is located 11 miles from Memorial Stadium and Littlejohn Coliseum, offering direct access to the lake with a shared dock and the possibility of a boat slip. This pet-friendly apartment features 3 bedrooms, 2 bathrooms, and accommodates up to 6 guests within its 1800 square feet, boasting a private balcony with sunset views, a full kitchen, air conditioning, and an electric fireplace.
Seneca, SC
07/16 – 07/20
$273/nighttotal: $1092 (4 )
8 Mi To Clemson: Peaceful Family Home W/ Yard
3 3
house , Seneca
This Seneca, South Carolina vacation home is located approximately 50 miles from Greenville-Spartanburg International Airport, offering easy access to local attractions. This 1400-square-foot house features three bedrooms, two bathrooms, accommodates up to 11 guests, and includes amenities such as a fully equipped kitchen, free Wi-Fi, air conditioning, a garden, parking, and a washer and dryer.